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- Title
An evolutionary test of the isoform switching hypothesis of functional progesterone withdrawal for parturition: humans have a weaker repressive effect of PR-A than mice.
- Authors
Wagner, Günter P; Tong, Yingchun; Emera, Deena; Romero, Roberto
- Abstract
A decrease in maternal serum progesterone (P4) concentrations precedes the onset of labor in most placental mammals. Humans differ by maintaining high levels of P4 throughout birth. Parturition in humans probably includes mechanisms that undercut the pregnancy sustaining function of P4. One attractive hypothesis is the isoform switching hypothesis (ISH). ISH is supported by in vitro evidence that progesterone receptor isoform A (PR-A) inhibits PR-B and that the PR-A/PR-B ratio increases towards term.
- Publication
Journal of perinatal medicine, 2012, Vol 40, Issue 4, p345
- ISSN
1619-3997
- Publication type
Journal Article
- DOI
10.1515/jpm-2011-0256