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- Title
Cancer antigen 125, human epididymis 4, kallikrein 6, osteopontin and soluble mesothelin-related peptide immunocomplexed with immunoglobulin M in epithelial ovarian cancer diagnosis.
- Authors
Bandiera, Elisabetta; Zanotti, Laura; Fabricio, Aline S C; Bucca, Elisa; Squarcina, Elisa; Romani, Chiara; Tassi, Renata; Bignotti, Eliana; Todeschini, Paola; Tognon, Germana; Romagnolo, Cesare; Gion, Massimo; Sartori, Enrico; Maggino, Tiziano; Pecorelli, Sergio; Ravaggi, Antonella
- Abstract
Human epididymis protein 4 (HE4), kallikrein 6 (KLK6), osteopontin (OPN) and soluble mesothelin-related peptide (SMRP) are new promising biomarkers that could integrate CA125 in epithelial ovarian cancer (EOC) diagnosis. The autoantibody response to tumor antigens is a potential tool for improving the diagnostic performances of biomarkers. The aim of this study was to assess the diagnostic potential of these biomarkers in the form of free markers and immunocomplexed with immunoglobulin M (IgM). Moreover, we analyzed the association between these markers and clinico-pathological characteristics of EOC patients.
- Publication
Clinical chemistry and laboratory medicine, 2013, Vol 51, Issue 9, p1815
- ISSN
1437-4331
- Publication type
Journal Article
- DOI
10.1515/cclm-2013-0151