Title: Efficient synthesis of 2,4-disubstituted thiazoles and 2-substituted 4-thiazolidinones under solvent free conditions.
Authors: Gautam, Deepika; Gautam, Poonam; Chaudhary, Ram P.
Abstract: Condensation of thiosemicarbazones 2 derived from 1-tetralones ( 1) with chloroacetic acid in presence of N-methylpyridinium tosylate (an ionic liquid) yields 2-substituted-4-thiazolidinones 3. The reaction of 2 with α-halo carbonyl compounds at room temperature under grinding conditions yields 2,4-disubstituted thiazoles 4 in excellent yields. The structures of compounds 2-4 have been established on the basis of elemental analysis, IR, NMR and mass spectral data.
Subjects: THIAZOLES; THIADIAZOLES; SOLVENTS; IONIC liquids; THIOSEMICARBAZONES; NUCLEAR magnetic resonance; MASS spectrometry
Publication: Heterocyclic Communications, 2011, Vol 17, Issue 3/4, p147
ISSN: 0793-0283
Publication type: Academic Journal
DOI: 10.1515/HC.2011.027

Efficient synthesis of 2,4-disubstituted thiazoles and 2-substituted 4-thiazolidinones under solvent free conditions.

Gautam, Deepika; Gautam, Poonam; Chaudhary, Ram P.