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- Title
Biochemistry of B-type natriuretic peptide--where are we now?
- Authors
Mair, Johannes
- Abstract
The discovery of the cardiac endocrine function more than 25 years ago was a breakthrough for the implementation of a routine laboratory marker of heart failure. The heart secretes two different natriuretic peptides with similar biological effects. B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) emerged as the superior diagnostic markers compared to circulating A-type natriuretic peptide (ANP) and proANP derived peptide forms. However, the biochemistry with the processing and metabolism of proBNP, NT-proBNP and BNP with their impact on BNP quantification are still incompletely understood.
- Publication
Clinical chemistry and laboratory medicine, 2008, Vol 46, Issue 11, p1507
- ISSN
1434-6621
- Publication type
Journal Article
- DOI
10.1515/CCLM.2008.295