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- Title
Expression of PSA-RP2, an alternatively spliced variant from the PSA gene, is increased in prostate cancer tissues but the protein is not secreted from prostate cancer cells.
- Authors
Whitbread, Astrid K; Veveris-Lowe, Tara L; Dong, Ying; Tan, Olivia L; Gardiner, Robert; Samaratunga, Hema M; Nicol, David L; Clements, Judith A
- Abstract
PSA-RP2 is a variant transcript expressed from the PSA gene that is conserved in gorillas, chimpanzees and humans suggesting a particular relevance for this transcript in these primates. We demonstrated by qRT-PCR that PSA-RP2 is upregulated in prostate cancer compared with benign prostatic hyperplasia tissues. The PSA-RP2 protein was not detected in seminal fluid and was cytoplasmically localised but not secreted from LNCaP or transfected PC3 prostate cells, despite secretion from transfected Cos-7 and HEK293 kidney cell lines. PSA-RP2-transfected PC3 cells showed slightly decreased proliferation and increased migration towards PC3-conditioned medium that could suggest a functional role in prostate cancer.
- Publication
Biological chemistry, 2010, Vol 391, Issue 4, p461
- ISSN
1437-4315
- Publication type
Journal Article
- DOI
10.1515/BC.2010.043