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- Title
Can Asperger syndrome be distinguished from autism? An anatomic likelihood meta-analysis of MRI studies.
- Authors
Yu, Kevin K; Cheung, Charlton; Chua, Siew E; McAlonan, Gráinne M
- Abstract
The question of whether Asperger syndrome can be distinguished from autism has attracted much debate and may even incur delay in diagnosis and intervention. Accordingly, there has been a proposal for Asperger syndrome to be subsumed under autism in the forthcoming Diagnostic and Statistical Manual of Mental Disorders, fifth edition, in 2013. One approach to resolve this question has been to adopt the criterion of absence of clinically significant language or cognitive delay--essentially, the "absence of language delay." To our knowledge, this is the first meta-analysis of magnetic resonance imaging (MRI) studies of people with autism to compare absence with presence of language delay. It capitalizes on the voxel-based morphometry (VBM) approach to systematically explore the whole brain for anatomic correlates of delay and no delay in language acquisition in people with autism spectrum disorders.
- Publication
Journal of psychiatry & neuroscience : JPN, 2011, Vol 36, Issue 6, p412
- ISSN
1488-2434
- Publication type
Journal Article
- DOI
10.1503/jpn.100138