We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacogenetics of antidepressant response.
- Authors
Porcelli, Stefano; Drago, Antonio; Fabbri, Chiara; Gibiino, Sara; Calati, Raffaella; Serretti, Alessandro
- Abstract
Personalized medicine - the adaptation of therapies based on an individual's genetic and molecular profile - is one of the most promising aspects of modern medicine. The identification of the relation between genotype and drug response, including both the therapeutic effect and side effect profile, is expected to deeply affect medical practice. In this paper, we review the current knowledge about the genes related to antidepressant treatment response and provide methodologic proposals for future studies. We have mainly focused on genes associated with pharmacodynamics, for which a list of promising genes has been identified despite some inconsistency across studies. We have also synthesized the main results for pharmacokinetic genes, although so far they seem less relevant than those for pharmaco dynamic genes. We discuss possible reasons for these inconsistent findings and propose new study designs.
- Publication
Journal of psychiatry & neuroscience : JPN, 2011, Vol 36, Issue 2, p87
- ISSN
1488-2434
- Publication type
Journal Article
- DOI
10.1503/jpn.100059