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- Title
Regulating the acrosome reaction.
- Authors
Florman, Harvey M; Jungnickel, Melissa K; Sutton, Keith A
- Abstract
The acrosome reaction is a secretory event that must be completed by the sperm of many animal species prior to fusion with eggs. In mammals, exocytosis in triggered by ZP3, a glycoprotein component of the egg pellucida, following gamete contact. ZP3 promotes a sustained influx of Ca2+ into sperm that is necessary for the acrosome reaction. Here, we discuss the mechanism by which ZP3 generates Ca2+ entry, as well as the upstream events leading to this influx and downstream processes that couple it with exocytosis.
- Publication
The International journal of developmental biology, 2008, Vol 52, Issue 5-6, p503
- ISSN
0214-6282
- Publication type
Journal Article
- DOI
10.1387/ijdb.082696hf