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- Title
The relationship between amyloid and tau.
- Authors
Hardy, John
- Abstract
Based on genetic findings, the relationship between the APP/Abeta and tau/tangle pathologies are discussed. It is argued that APP/Abeta is upstream of tau/tangle in the Alzheimer pathogenesis, and that the relationship between the pathologies are promiscuous in two ways: first, APP/Abeta can equally be seen to be upstream of synuclein/Lewy bodies in cell death pathways, and second, tau pathology can be initiated by genetic lesions in other pathways.
- Publication
Journal of molecular neuroscience : MN, 2003, Vol 20, Issue 2, p203
- ISSN
0895-8696
- Publication type
Journal Article
- DOI
10.1385/JMN:20:2:203