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- Title
Genome-wide association study of height and body mass index in Australian twin families.
- Authors
Liu, Jimmy Z; Medland, Sarah E; Wright, Margaret J; Henders, Anjali K; Heath, Andrew C; Madden, Pamela A F; Duncan, Alexis; Montgomery, Grant W; Martin, Nicholas G; McRae, Allan F
- Abstract
Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at approximately 550,000 genotyped SNPs. We identified a single genome-wide significant variant for height (P value=1.06x10(-9)) located in HHIP, a well-replicated height-associated gene. Suggestive levels of association were found for other known genes associated with height (P values<1x10(-6)): ADAMTSL3, EFEMP1, GPR126, and HMGA2; and BMI (P values<1x10(-4)): FTO and MC4R. Together, these variants explain less than 2% of total phenotypic variation for height and 0.5% for BMI.
- Publication
Twin research and human genetics : the official journal of the International Society for Twin Studies, 2010, Vol 13, Issue 2, p179
- ISSN
1832-4274
- Publication type
Journal Article
- DOI
10.1375/twin.13.2.179