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- Title
Improved reflexive testing algorithm for hepatitis C infection using signal-to-cutoff ratios of a hepatitis C virus antibody assay.
- Authors
Lai, Keane K Y; Jin, Ming; Yuan, Shan; Larson, Meaghan F; Dominitz, Jason A; Bankson, Daniel D
- Abstract
Chemiluminescence immunoassay (CIA) is used to detect hepatitis C virus (HCV) antibody status on the basis of signal-to-cutoff (S/Co) ratios. Positive results of antibody to HCV (anti-HCV) are followed by either recombinant immunoblot assay (RIBA) to confirm anti-HCV positivity or reverse transcription (RT)-PCR to detect viremia. We hypothesized that by analyzing S/Co ratios, we could determine a strategy to reduce unnecessary supplementary testing in our population.
- Publication
Clinical chemistry, 2011, Vol 57, Issue 7, p1050
- ISSN
1530-8561
- Publication type
Journal Article
- DOI
10.1373/clinchem.2010.158691