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- Title
Analysis of the size distributions of fetal and maternal cell-free DNA by paired-end sequencing.
- Authors
Fan, H Christina; Blumenfeld, Yair J; Chitkara, Usha; Hudgins, Louanne; Quake, Stephen R
- Abstract
Noninvasive prenatal diagnosis with cell-free DNA in maternal plasma is challenging because only a small portion of the DNA sample is derived from the fetus. A few previous studies provided size-range estimates of maternal and fetal DNA, but direct measurement of the size distributions is difficult because of the small quantity of cell-free DNA.
- Publication
Clinical chemistry, 2010, Vol 56, Issue 8, p1279
- ISSN
1530-8561
- Publication type
Journal Article
- DOI
10.1373/clinchem.2010.144188