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- Title
Sweetening the pot: adding glycosylation to the biomarker discovery equation.
- Authors
Drake, Penelope M; Cho, Wonryeon; Li, Bensheng; Prakobphol, Akraporn; Johansen, Eric; Anderson, N Leigh; Regnier, Fred E; Gibson, Bradford W; Fisher, Susan J
- Abstract
Cancer has profound effects on gene expression, including a cell's glycosylation machinery. Thus, tumors produce glycoproteins that carry oligosaccharides with structures that are markedly different from the same protein produced by a normal cell. A single protein can have many glycosylation sites that greatly amplify the signals they generate compared with their protein backbones.
- Publication
Clinical chemistry, 2010, Vol 56, Issue 2, p223
- ISSN
1530-8561
- Publication type
Journal Article
- DOI
10.1373/clinchem.2009.136333