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- Title
Comparison of multiplex immunoassay platforms.
- Authors
Fu, Qin; Zhu, Jie; Van Eyk, Jennifer E
- Abstract
Candidate biomarkers discovered with high-throughput proteomic techniques (along with many biomarkers reported in the literature) must be rigorously validated. The simultaneous quantitative assessment of multiple potential biomarkers across large cohorts presents a major challenge to the field. Multiplex immunoassays represent a promising solution, with the potential to provide quantitative data via parallel analyses. These assays also require substantially less sample and reagents than the traditional ELISA (which is further limited by its ability to measure only a single antigen). We have measured the reproducibility, reliability, robustness, accuracy, and throughput of commercially available multiplex immunoassays to ascertain their suitability for serum biomarker analysis and validation.
- Publication
Clinical chemistry, 2010, Vol 56, Issue 2, p314
- ISSN
1530-8561
- Publication type
Journal Article
- DOI
10.1373/clinchem.2009.135087