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- Title
Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21.
- Authors
Tsui, Nancy B Y; Akolekar, Ranjit; Chiu, Rossa W K; Chow, Katherine C K; Leung, Tak Y; Lau, Tze K; Nicolaides, Kypros H; Lo, Y M Dennis
- Abstract
Maternal plasma mRNA encoded by the PLAC4 gene (placenta-specific 4), which is transcribed from chromosome 21 in placental cells, is a potential marker for the noninvasive assessment of chromosome 21 dosage in the fetus. We evaluated the diagnostic sensitivities and specificities of 2 trisomy 21-screening approaches that use maternal plasma PLAC4 mRNA.
- Publication
Clinical chemistry, 2010, Vol 56, Issue 1, p73
- ISSN
1530-8561
- Publication type
Journal Article
- DOI
10.1373/clinchem.2009.132662