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- Title
Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas.
- Authors
Zhang, Yuwei; Calado, Rodrigo; Rao, Mahadev; Hong, Julie A; Meeker, Alan K; Dumitriu, Bogdan; Atay, Scott; McCormick, Peter J; Garfield, Susan H; Wangsa, Danny; Padilla-Nash, Hesed M; Burkett, Sandra; Zhang, Mary; Kunst, Tricia F; Peterson, Nathan R; Xi, Sichuan; Inchauste, Suzanne; Altorki, Nasser K; Casson, Alan G; Beer, David G; Harris, Curtis C; Ried, Thomas; Young, Neal S; Schrump, David S
- Abstract
Although implicated in the pathogenesis of several chronic inflammatory disorders and hematologic malignancies, telomerase mutations have not been thoroughly characterized in human cancers. The present study was performed to examine the frequency and potential clinical relevance of telomerase mutations in esophageal carcinomas.
- Publication
PloS one, 2014, Vol 9, Issue 7, pe101010
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0101010