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- Title
Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.
- Authors
Kauder, Steven E; Santell, Lydia; Mai, Elaine; Wright, Lilyan Y; Luis, Elizabeth; N'Diaye, Elsa N; Lutman, Jeff; Ratti, Navneet; Sa, Susan M; Maun, Henry R; Stefanich, Eric; Gonzalez, Lino C; Graham, Robert R; Diehl, Lauri; Faubion, William A, Jr; Keir, Mary E; Young, Judy; Chaudhuri, Amitabha; Lazarus, Robert A; Egen, Jackson G
- Abstract
Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON). A non-synonymous coding variant in MSP (689C) has been associated with genetic susceptibility to both Crohn's disease and ulcerative colitis, two major types of inflammatory bowel disease (IBD) characterized by chronic inflammation of the digestive tract. We investigated the consequences of this polymorphism for MSP-RON pathway activity and IBD pathogenesis.
- Publication
PloS one, 2013, Vol 8, Issue 12, pe83958
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0083958