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- Title
Phosphoproteomics and bioinformatics analyses of spinal cord proteins in rats with morphine tolerance.
- Authors
Liaw, Wen-Jinn; Tsao, Cheng-Ming; Huang, Go-Shine; Wu, Chin-Chen; Ho, Shung-Tai; Wang, Jhi-Joung; Tao, Yuan-Xiang; Shui, Hao-Ai
- Abstract
Morphine is the most effective pain-relieving drug, but it can cause unwanted side effects. Direct neuraxial administration of morphine to spinal cord not only can provide effective, reliable pain relief but also can prevent the development of supraspinal side effects. However, repeated neuraxial administration of morphine may still lead to morphine tolerance.
- Publication
PloS one, 2014, Vol 9, Issue 1, pe83817
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0083817