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- Title
Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells.
- Authors
Lin, Li; Hutzen, Brian; Lee, Hsiu-Fang; Peng, Zhengang; Wang, Wenlong; Zhao, Chongqiang; Lin, Huey-Jen; Sun, Duxin; Li, Pui-Kai; Li, Chenglong; Korkaya, Hasan; Wicha, Max S; Lin, Jiayuh
- Abstract
STAT3 activation is frequently detected in breast cancer and this pathway has emerged as an attractive molecular target for cancer treatment. Recent experimental evidence suggests ALDH-positive (ALDH(+)), or cell surface molecule CD44-positive (CD44(+)) but CD24-negative (CD24(-)) breast cancer cells have cancer stem cell properties. However, the role of STAT3 signaling in ALDH(+) and ALDH(+)/CD44(+)/CD24(-) subpopulations of breast cancer cells is unknown.
- Publication
PloS one, 2013, Vol 8, Issue 12, pe82821
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0082821