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- Title
Comparison of HER2 and phospho-HER2 expression between biopsy and resected breast cancer specimens using a quantitative assessment method.
- Authors
Bai, Yalai; Cheng, Huan; Bordeaux, Jennifer; Neumeister, Veronique; Kumar, Sudha; Rimm, David L; Stern, David F
- Abstract
HER2/Neu (ErbB-2) overexpression, which occurs in 15-20% of breast cancer cases, is associated with better response to treatment with the drug trastuzumab. PhosphoHER2 (pHER2) has been evaluated for prediction of response to trastuzumab. Both markers are heterogeneously detected and are potentially subject to loss as a consequence of delayed time to fixation. Here, we quantitatively assess both markers in core needle biopsies (CNBs) and matched tumor resections to assess concordance between the core and the resection and between HER2 and pHER2.
- Publication
PloS one, 2013, Vol 8, Issue 11, pe79901
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0079901