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- Title
MicroRNA-26a inhibits angiogenesis by down-regulating VEGFA through the PIK3C2α/Akt/HIF-1α pathway in hepatocellular carcinoma.
- Authors
Chai, Zong-Tao; Kong, Jian; Zhu, Xiao-Dong; Zhang, Yuan-Yuan; Lu, Lu; Zhou, Jia-Min; Wang, Long-Rong; Zhang, Ke-Zhi; Zhang, Qiang-Bo; Ao, Jian-Yang; Wang, Miao; Wu, Wei-Zhong; Wang, Lu; Tang, Zhao-You; Sun, Hui-Chuan
- Abstract
microRNAs (miRNAs) have been reported to regulate angiogenesis by down-regulating the expression of pro-angiogenic or anti-angiogenic factors. The aims of this study were to investigate whether miR-26a inhibited angiogenesis by down-regulating vascular endothelial growth factor A (VEGFA) and its clinical relevance in hepatocellular carcinoma (HCC).
- Publication
PloS one, 2013, Vol 8, Issue 10, pe77957
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0077957