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- Title
Adenoviral-mediated placental gene transfer of IGF-1 corrects placental insufficiency via enhanced placental glucose transport mechanisms.
- Authors
Jones, Helen N; Crombleholme, Timothy; Habli, Mounira
- Abstract
Previous work in our laboratory demonstrated that over-expression of human insulin-like growth factor -1 (hIGF-1) in the placenta corrects fetal weight deficits in mouse, rat, and rabbit models of intrauterine growth restriction without changes in placental weight. The underlying mechanisms of this effect have not been elucidated. To investigate the effect of intra-placental IGF-1 over-expression on placental function we examined glucose transporter expression and localization in both a mouse model of IUGR and a model of human trophoblast, the BeWo Choriocarcinoma cell line.
- Publication
PloS one, 2013, Vol 8, Issue 9, pe74632
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0074632