We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hepatocyte expression of the senescence marker p21 is linked to fibrosis and an adverse liver-related outcome in alcohol-related liver disease.
- Authors
Aravinthan, Aloysious; Pietrosi, Giada; Hoare, Matthew; Jupp, James; Marshall, Aileen; Verrill, Clare; Davies, Susan; Bateman, Adrian; Sheron, Nick; Allison, Michael; Alexander, Graeme J M
- Abstract
Alcohol-related liver disease (ALD) remains a leading cause of liver-related morbidity and mortality. Age, fibrosis stage, MELD score and continued alcohol consumption predict outcome in everyday clinical practice. In previous studies increased hepatocyte nuclear area and hepatocyte expression of p21, both markers of senescence, were associated with increased fibrosis stage and a poor outcome in non-alcohol-related fatty liver disease, while increased hepatocyte nuclear area was related to liver dysfunction in ALD cirrhosis. This study, therefore, investigated the pattern of hepatocyte cell cycle phase distribution and hepatocyte p21 expression in relation to outcome in ALD.
- Publication
PloS one, 2013, Vol 8, Issue 9, pe72904
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0072904