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- Title
Modulation of ocular surface glycocalyx barrier function by a galectin-3 N-terminal deletion mutant and membrane-anchored synthetic glycopolymers.
- Authors
Mauris, Jerome; Mantelli, Flavio; Woodward, Ashley M; Cao, Ziyhi; Bertozzi, Carolyn R; Panjwani, Noorjahan; Godula, Kamil; Argüeso, Pablo
- Abstract
Interaction of transmembrane mucins with the multivalent carbohydrate-binding protein galectin-3 is critical to maintaining the integrity of the ocular surface epithelial glycocalyx. This study aimed to determine whether disruption of galectin-3 multimerization and insertion of synthetic glycopolymers in the plasma membrane could be used to modulate glycocalyx barrier function in corneal epithelial cells.
- Publication
PloS one, 2013, Vol 8, Issue 8, pe72304
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0072304