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- Title
Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells.
- Authors
Fei, Shi-Jiang; Zhang, Xu-Chao; Dong, Song; Cheng, Hua; Zhang, Yi-Fang; Huang, Ling; Zhou, Hai-Yu; Xie, Zhi; Chen, Zhi-Hong; Wu, Yi-Long
- Abstract
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown dramatic clinical benefits in advanced non-small cell lung cancer (NSCLC); however, resistance remains a serious problem in clinical practice. The present study analyzed mTOR-associated signaling-pathway differences between the EGFR TKI-sensitive and -resistant NSCLC cell lines and investigated the feasibility of targeting mTOR with specific mTOR inhibitor in EGFR TKI resistant NSCLC cells.
- Publication
PloS one, 2013, Vol 8, Issue 7, pe69104
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0069104