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- Title
Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction.
- Authors
Tamaki, Shunsuke; Mano, Toshiaki; Sakata, Yasushi; Ohtani, Tomohito; Takeda, Yasuharu; Kamimura, Daisuke; Omori, Yosuke; Tsukamoto, Yasumasa; Ikeya, Yukitoshi; Kawai, Mari; Kumanogoh, Atsushi; Hagihara, Keisuke; Ishii, Ryohei; Higashimori, Mitsuru; Kaneko, Makoto; Hasuwa, Hidetoshi; Miwa, Takeshi; Yamamoto, Kazuhiro; Komuro, Issei
- Abstract
Chronic heart failure (CHF) with preserved left ventricular (LV) ejection fraction (HFpEF) is observed in half of all patients with CHF and carries the same poor prognosis as CHF with reduced LV ejection fraction (HFrEF). In contrast to HFrEF, there is no established therapy for HFpEF. Chronic inflammation contributes to cardiac fibrosis, a crucial factor in HFpEF; however, inflammatory mechanisms and mediators involved in the development of HFpEF remain unclear. Therefore, we sought to identify novel inflammatory mediators involved in this process.
- Publication
PloS one, 2013, Vol 8, Issue 7, pe68893
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0068893