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- Title
Shear stress regulates late EPC differentiation via mechanosensitive molecule-mediated cytoskeletal rearrangement.
- Authors
Cheng, Min; Guan, Xiumei; Li, Hong; Cui, Xiaodong; Zhang, Xiaoyun; Li, Xin; Jing, Xu; Wu, Haiyan; Avsar, Emil
- Abstract
Previous studies have demonstrated that endothelial progenitor cells (EPCs), in particular late EPCs, play important roles in endothelial maintenance and repair. Recent evidence has revealed shear stress as a key regulator for EPC differentiation. However, the underlying mechanisms regulating the shear stress-induced EPC differentiation have not been understood completely. The present study was undertaken to further investigate the effects of shear stress on the late EPC differentiation, and to elucidate the signal mechanism involved.
- Publication
PloS one, 2013, Vol 8, Issue 7, pe67675
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0067675