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- Title
Type 1 interferons inhibit myotube formation independently of upregulation of interferon-stimulated gene 15.
- Authors
Franzi, Sara; Salajegheh, Mohammad; Nazareno, Remedios; Greenberg, Steven A
- Abstract
Type 1 interferon (IFN)-inducible genes and their inducible products are upregulated in dermatomyositis muscle. Of these, IFN-stimulated gene 15 (ISG15) is one of the most upregulated, suggesting its possible involvement in the pathogenesis of this disease. To test this postulate, we developed a model of type 1 IFN mediated myotube toxicity and assessed whether or not downregulation of ISG15 expression prevents this toxicity.
- Publication
PloS one, 2013, Vol 8, Issue 6, pe65362
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0065362