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- Title
Evolution of smooth tubercle Bacilli PE and PE_PGRS genes: evidence for a prominent role of recombination and imprint of positive selection.
- Authors
Namouchi, Amine; Karboul, Anis; Fabre, Michel; Gutierrez, Maria Cristina; Mardassi, Helmi
- Abstract
PE and PE_PGRS are two mycobateria-restricted multigene families encoding membrane associated and secreted proteins that have expanded mainly in the pathogenic species, notably the Mycobacterium tuberculosis complex (MTBC). Several lines of evidence attribute to PE and PE_PGRS genes critical roles in mycobacterial pathogenicity. To get more insight into the nature of these genes, we sought to address their evolutionary trajectories in the group of smooth tubercle bacilli (STB), the putative ancestor of the clonal MTBC.
- Publication
PloS one, 2013, Vol 8, Issue 5, pe64718
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0064718