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- Title
Mitochondrial genetic background modifies the relationship between traffic-related air pollution exposure and systemic biomarkers of inflammation.
- Authors
Wittkopp, Sharine; Staimer, Norbert; Tjoa, Thomas; Gillen, Daniel; Daher, Nancy; Shafer, Martin; Schauer, James J; Sioutas, Constantinos; Delfino, Ralph J
- Abstract
Mitochondria are the main source of reactive oxygen species (ROS). Human mitochondrial haplogroups are linked to differences in ROS production and oxidative-stress induced inflammation that may influence disease pathogenesis, including coronary artery disease (CAD). We previously showed that traffic-related air pollutants were associated with biomarkers of systemic inflammation in a cohort panel of subjects with CAD in the Los Angeles air basin.
- Publication
PloS one, 2013, Vol 8, Issue 5, pe64444
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0064444