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- Title
Propensity score estimation to address calendar time-specific channeling in comparative effectiveness research of second generation antipsychotics.
- Authors
Dusetzina, Stacie B; Mack, Christina D; Stürmer, Til
- Abstract
Channeling occurs when a medication and its potential comparators are selectively prescribed based on differences in underlying patient characteristics. Drug safety advisories can provide new information regarding the relative safety or effectiveness of a drug product which might increase selective prescribing. In particular, when reported adverse effects vary among drugs within a therapeutic class, clinicians may channel patients toward or away from a drug based on the patient's underlying risk for an adverse outcome. If channeling is not identified and appropriately managed it might lead to confounding in observational comparative effectiveness studies.
- Publication
PloS one, 2013, Vol 8, Issue 5, pe63973
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0063973