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- Title
AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy.
- Authors
Spindler, Matthew J; Burmeister, Brian T; Huang, Yu; Hsiao, Edward C; Salomonis, Nathan; Scott, Mark J; Srivastava, Deepak; Carnegie, Graeme K; Conklin, Bruce R
- Abstract
A-kinase anchoring proteins (AKAPs) are scaffolding molecules that coordinate and integrate G-protein signaling events to regulate development, physiology, and disease. One family member, AKAP13, encodes for multiple protein isoforms that contain binding sites for protein kinase A (PKA) and D (PKD) and an active Rho-guanine nucleotide exchange factor (Rho-GEF) domain. In mice, AKAP13 is required for development as null embryos die by embryonic day 10.5 with cardiovascular phenotypes. Additionally, the AKAP13 Rho-GEF and PKD-binding domains mediate cardiomyocyte hypertrophy in cell culture. However, the requirements for the Rho-GEF and PKD-binding domains during development and cardiac hypertrophy are unknown.
- Publication
PloS one, 2013, Vol 8, Issue 4, pe62705
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0062705