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- Title
Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury.
- Authors
Siddall, Hilary K; Yellon, Derek M; Ong, Sang-Bing; Mukherjee, Uma A; Burke, Niall; Hall, Andrew R; Angelova, Plamena R; Ludtmann, Marthe H R; Deas, Emma; Davidson, Sean M; Mocanu, Mihaela M; Hausenloy, Derek J
- Abstract
Mutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson's disease. Although PINK1 is present in the heart its exact role there is unclear. We hypothesized that PINK1 protects the heart against acute ischemia reperfusion injury (IRI) by preventing mitochondrial dysfunction.
- Publication
PloS one, 2013, Vol 8, Issue 4, pe62400
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0062400