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- Title
The PI3K/AKT/mTOR signaling pathway is overactivated in primary aldosteronism.
- Authors
Su, Hengchuan; Gu, Yanyun; Li, Fengying; Wang, Qidi; Huang, Baoxing; Jin, Xiaolong; Ning, Guang; Sun, Fukang
- Abstract
To date, the available non-invasive remedies for primary aldosteronism are not satisfactory in clinical practice. The phosphoinositide 3-kinase (PI3Ks)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway is essential for tumorigenesis and metastasis in many types of human tumors, including renal cancer, adrenal carcinoma and pheochromocytoma. The possibility that this pathway is also necessary for the pathogenesis of primary aldosteronism has not yet been explored. To answer this question, we investigated the activity of the PI3K/AKT/mTOR signaling pathway in normal adrenal glands (NAGs), primary aldosteronism (PA) patients and NCI-H295R cells.
- Publication
PloS one, 2013, Vol 8, Issue 4, pe62399
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0062399