We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Engineering agatoxin, a cystine-knot peptide from spider venom, as a molecular probe for in vivo tumor imaging.
- Authors
Moore, Sarah J; Leung, Cheuk Lun; Norton, Heidi K; Cochran, Jennifer R
- Abstract
Cystine-knot miniproteins, also known as knottins, have shown great potential as molecular scaffolds for the development of targeted therapeutics and diagnostic agents. For this purpose, previous protein engineering efforts have focused on knottins based on the Ecballium elaterium trypsin inhibitor (EETI) from squash seeds, the Agouti-related protein (AgRP) neuropeptide from mammals, or the Kalata B1 uterotonic peptide from plants. Here, we demonstrate that Agatoxin (AgTx), an ion channel inhibitor found in spider venom, can be used as a molecular scaffold to engineer knottins that bind with high-affinity to a tumor-associated integrin receptor.
- Publication
PloS one, 2013, Vol 8, Issue 4, pe60498
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0060498