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- Title
Global identification of genes related to nutrient deficiency in intervertebral disc cells in an experimental nutrient deprivation model.
- Authors
Sudo, Hideki; Yamada, Katsuhisa; Iwasaki, Koji; Higashi, Hideaki; Ito, Manabu; Minami, Akio; Iwasaki, Norimasa
- Abstract
Intervertebral disc degeneration is a significant cause of degenerative spinal diseases. Nucleus pulposus (NP) cells reportedly fail to survive in large degenerated discs with limited nutrient availability. Therefore, understanding the regulatory mechanism of the molecular response of NP cells to nutrient deprivation may reveal a new strategy to treat disc degeneration. This study aimed to identify genes related to nutrient deprivation in NP cells on a global scale in an experimental nutrient deprivation model.
- Publication
PloS one, 2013, Vol 8, Issue 3, pe58806
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0058806