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- Title
Macrophage migration inhibitory factor inhibition is deleterious for high-fat diet-induced cardiac dysfunction.
- Authors
Palud, Aurore; Marciniak, Camille; Montaigne, David; Marechal, Xavier; Ballot, Caroline; Hassoun, Sidi Mohamed; Decoster, Brigitte; Neviere, Remi; Lancel, Steve
- Abstract
Development of metabolic syndrome is associated with impaired cardiac performance, mitochondrial dysfunction and pro-inflammatory cytokine increase, such as the macrophage migration inhibitory factor MIF. Depending on conditions, MIF may exert both beneficial and deleterious effects on the myocardium. Therefore, we tested whether pharmacological inhibition of MIF prevented or worsened metabolic syndrome-induced myocardial dysfunction.
- Publication
PloS one, 2013, Vol 8, Issue 3, pe58718
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0058718