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- Title
Differential expression of the RANKL/RANK/OPG system is associated with bone metastasis in human non-small cell lung cancer.
- Authors
Peng, Xianbo; Guo, Wei; Ren, Tingting; Lou, Zhiyuan; Lu, Xinchang; Zhang, Shuai; Lu, Qunshan; Sun, Yifeng
- Abstract
Human non-small cell lung cancer (NSCLC) patients exhibit a high propensity to develop skeletal metastasis, resulting in excessive osteolytic activity. The RANKL/RANK/OPG system, which plays a pivotal role in bone remodeling by regulating osteoclast formation and activity, is of potential interest in this context.
- Publication
PloS one, 2013, Vol 8, Issue 3, pe58361
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0058361