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- Title
Identifying correlations between chromosomal proximity of genes and distance of their products in protein-protein interaction networks of yeast.
- Authors
Santoni, Daniele; Castiglione, Filippo; Paci, Paola
- Abstract
In this article we present evidence for a relationship between chromosome gene loci and the topological properties of the protein-protein interaction network corresponding to the set of genes under consideration. Specifically, for each chromosome of the Saccharomyces cerevisiae genome, the distribution of the intra-chromosome inter-gene distances was analyzed and a positive correlation with the distance among the corresponding proteins of the protein-protein interaction network was found. In order to study this relationship we used concepts based on non-parametric statistics and information theory. We provide statistical evidence that if two genes are closely located, then it is likely that their protein products are closely located in the protein-protein interaction network, or in other words, that they are involved in the same biological process.
- Publication
PloS one, 2013, Vol 8, Issue 3, pe57707
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0057707