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- Title
Changes in innate and permissive immune responses after hbv transgenic mouse vaccination and long-term-siRNA treatment [corrected].
- Authors
Ren, Guang-Li; Huang, Guang-Yu; Zheng, Hong; Fang, Ying; Ma, Heng-Hao; Xu, Man-Chun; Zhang, Hong-Bin; Zhang, Wei-Yun; Zhao, Ya-Gang; Sun, Da-Yong; Hu, Wen-Kui; Liu, Jian
- Abstract
Currently, no licensed therapy can thoroughly eradicate hepatitis B virus (HBV) from the body, including interferon α and inhibitors of HBV reverse-transcription. Small interfering RNA (siRNA) seem to be a promising tool for treating HBV, but had no effect on the pre-existing HBV covalently closed circular DNA. Because it is very difficult to thoroughly eradicate HBV with unique siRNAs, upgrading the immune response is the best method for fighting HBV infection. Here, we aim to explore the immune response of transgenic mice to HBV vaccination after long-term treatment with siRNAs and develop a therapeutic approach that combines siRNAs with immunopotentiators.
- Publication
PloS one, 2013, Vol 8, Issue 3, pe57525
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0057525