We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pathogenic role of basic calcium phosphate crystals in destructive arthropathies.
- Authors
Ea, Hang-Korng; Chobaz, Véronique; Nguyen, Christelle; Nasi, Sonia; van Lent, Peter; Daudon, Michel; Dessombz, Arnaud; Bazin, Dominique; McCarthy, Geraldine; Jolles-Haeberli, Brigitte; Ives, Annette; Van Linthoudt, Daniel; So, Alexander; Lioté, Frédéric; Busso, Nathalie
- Abstract
basic calcium phosphate (BCP) crystals are commonly found in osteoarthritis (OA) and are associated with cartilage destruction. BCP crystals induce in vitro catabolic responses with the production of metalloproteases and inflammatory cytokines such as interleukin-1 (IL-1). In vivo, IL-1 production induced by BCP crystals is both dependant and independent of NLRP3 inflammasome. We aimed to clarify 1/ the role of BCP crystals in cartilage destruction and 2/ the role of IL-1 and NLRP3 inflammasome in cartilage degradation related to BCP crystals.
- Publication
PloS one, 2013, Vol 8, Issue 2, pe57352
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0057352