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- Title
Enhanced sensitivity to low dose irradiation of ApoE-/- mice mediated by early pro-inflammatory profile and delayed activation of the TGFβ1 cascade involved in fibrogenesis.
- Authors
Monceau, Virginie; Meziani, Lydia; Strup-Perrot, Carine; Morel, Eric; Schmidt, Magret; Haagen, Julia; Escoubet, Brigitte; Dörr, Wolfgang; Vozenin, Marie-Catherine
- Abstract
Investigating long-term cardiac effects of low doses of ionizing radiation is highly relevant in the context of interventional cardiology and radiotherapy. Epidemiological data report that low doses of irradiation to the heart can result in significant increase in the cardiovascular mortality by yet unknown mechanisms. In addition co-morbidity factor such as hypertension or/and atherosclerosis can enhance cardiac complications. Therefore, we explored the mechanisms that lead to long-term cardiac remodelling and investigated the interaction of radiation-induced damage to heart and cardiovascular systems with atherosclerosis, using wild-type and ApoE-deficient mice.
- Publication
PloS one, 2013, Vol 8, Issue 2, pe57052
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0057052