We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Testing a capacity-load model for hypertension: disentangling early and late growth effects on childhood blood pressure in a prospective birth cohort.
- Authors
Grijalva-Eternod, Carlos S; Lawlor, Debbie A; Wells, Jonathan C K
- Abstract
In 2005, it was estimated that hypertension affected 26.4% of the adult population worldwide. By 2025, it is predicted that it will affect about 60% of adults, a total of 1.56 billion. Both pre- and postnatal growth patterns have been associated with later blood pressure (BP), but in contrasting directions. These inconsistent associations of growth during different developmental periods merit elucidation. We tested a theoretical model treating birth weight as a marker of homeostatic metabolic capacity, and childhood height, lean mass and fat mass as independent indices of metabolic load. We predicted that decreased capacity and increased load would be independently associated with increased BP.
- Publication
PloS one, 2013, Vol 8, Issue 2, pe56078
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0056078