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- Title
Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner.
- Authors
Borissoff, Julian I; Otten, Jeroen J T; Heeneman, Sylvia; Leenders, Peter; van Oerle, René; Soehnlein, Oliver; Loubele, Sarah T B G; Hamulyák, Karly; Hackeng, Tilman M; Daemen, Mat J A P; Degen, Jay L; Weiler, Hartmut; Esmon, Charles T; van Ryn, Joanne; Biessen, Erik A L; Spronk, Henri M H; ten Cate, Hugo
- Abstract
Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects of coagulation proteases. Published experimental studies have yielded contradictory findings on the role of hypercoagulability in atherogenesis. We therefore sought to address this matter by extensively investigating the in vivo significance of genetic alterations and pharmacologic inhibition of thrombin formation for the onset and progression of atherosclerosis, and plaque phenotype determination.
- Publication
PloS one, 2013, Vol 8, Issue 2, pe55784
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0055784