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- Title
Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV.
- Authors
Lindegaard, Birgitte; Hvid, Thine; Grøndahl, Thomas; Frosig, Christian; Gerstoft, Jan; Hojman, Pernille; Pedersen, Bente Klarlund
- Abstract
Fibroblast growth factor (FGF)-21 is a novel regulator of glucose and lipid metabolism. Recently, increased FGF-21 mRNA expression in muscle was found in patients with type 2 diabetes, but the role for FGF-21 in muscle is not well understood. Patients with HIV-infection and lipodystrophy are characterised by various degree of lipid-driven insulin resistance. We hypothesized that muscle FGF-21 mRNA would be altered in HIV patients with lipodystrophy.
- Publication
PloS one, 2013, Vol 8, Issue 3, pe55632
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0055632