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- Title
Does malaria affect placental development? Evidence from in vitro models.
- Authors
Umbers, Alexandra J; Stanisic, Danielle I; Ome, Maria; Wangnapi, Regina; Hanieh, Sarah; Unger, Holger W; Robinson, Leanne J; Lufele, Elvin; Baiwog, Francesca; Siba, Peter M; King, Christopher L; Beeson, James G; Mueller, Ivo; Aplin, John D; Glazier, Jocelyn D; Rogerson, Stephen J
- Abstract
Malaria in early pregnancy is difficult to study but has recently been associated with fetal growth restriction (FGR). The pathogenic mechanisms underlying malarial FGR are poorly characterized, but may include impaired placental development. We used in vitro methods that model migration and invasion of placental trophoblast into the uterine wall to investigate whether soluble factors released into maternal blood in malaria infection might impair placental development. Because trophoblast invasion is enhanced by a number of hormones and chemokines, and is inhibited by pro-inflammatory cytokines, many of which are dysregulated in malaria in pregnancy, we further compared concentrations of these factors in blood between malaria-infected and uninfected pregnancies.
- Publication
PloS one, 2013, Vol 8, Issue 1, pe55269
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0055269