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- Title
Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes.
- Authors
Laforenza, Umberto; Scaffino, Manuela F; Gastaldi, Giulia
- Abstract
Glycerol outflow from adipocytes has been considered for a decade to be mediated by aquaporin-7, an aquaglyceroporin highly expressed in the adipose tissue. Its involvement in glycerol metabolism has been widely studied also in humans. Recent studies in different aquaporin-7 KO mice models pose two different questions 1) the exact localization of aquaporin-7 in human white adipose tissue; 2) the existence of other aquaglyceroporins that work with aquaporin-7 to guarantee glycerol efflux and thus a normal adiposity in humans. To this purpose we investigated the expression, the localization and the functioning of aquaglyceroporin-10 in subcutaneous white adipose tissue, in isolated and cultured differentiated adipocytes.
- Publication
PloS one, 2013, Vol 8, Issue 1, pe54474
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0054474