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- Title
The role of hypoxia-inducible factor 1α in determining the properties of castrate-resistant prostate cancers.
- Authors
Ranasinghe, Weranja K B; Xiao, Lin; Kovac, Suzana; Chang, Mike; Michiels, Carine; Bolton, Damien; Shulkes, Arthur; Baldwin, Graham S; Patel, Oneel
- Abstract
Castrate-resistant prostate cancer (CRPC) is a lethal condition in patients receiving androgen deprivation therapy for prostate cancer (PC). Despite numerous studies showing the expression of HIF1α protein under normoxia in PC cell lines, the role of this normoxic HIF1α expression in chemo-resistance and migration has not been investigated previously. As no method is currently available to determine which tumors will progress to CRPC, the role of HIF1α in PC and its potential for predicting the development of CRPC was also investigated.
- Publication
PloS one, 2013, Vol 8, Issue 1, pe54251
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0054251