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- Title
Effects of warm ischemic time on gene expression profiling in colorectal cancer tissues and normal mucosa.
- Authors
Musella, Valeria; Verderio, Paolo; Reid, James Francis; Pizzamiglio, Sara; Gariboldi, Manuela; Callari, Maurizio; Milione, Massimo; De Cecco, Loris; Veneroni, Silvia; Pierotti, Marco Alessandro; Daidone, Maria Grazia
- Abstract
Genome-wide gene expression analyses of tumors are a powerful tool to identify gene signatures associated with biologically and clinically relevant characteristics and for several tumor types are under clinical validation by prospective trials. However, handling and processing of clinical specimens may significantly affect the molecular data obtained from their analysis. We studied the effects of tissue handling time on gene expression in human normal and tumor colon tissues undergoing routine surgical procedures.
- Publication
PloS one, 2013, Vol 8, Issue 1, pe53406
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0053406