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- Title
Intracellular function of interleukin-1 receptor antagonist in ischemic cardiomyocytes.
- Authors
Vecile, Elena; Dobrina, Aldo; Salloum, Fadi N; Van Tassell, Benjamin W; Falcione, Antonella; Gustini, Edoardo; Secchiero, Samuele; Crovella, Sergio; Sinagra, Gianfranco; Finato, Nicoletta; Nicklin, Martin J; Abbate, Antonio
- Abstract
Loss of cardiac myocytes due to apoptosis is a relevant feature of ischemic heart disease. It has been described in infarct and peri-infarct regions of the myocardium in coronary syndromes and in ischemia-linked heart remodeling. Previous studies have provided protection against ischemia-induced cardiomyocyte apoptosis by the anti-inflammatory cytokine interleukin-1 receptor-antagonist (IL-1Ra). Mitochondria triggering of caspases plays a central role in ischemia-induced apoptosis. We examined the production of IL-1Ra in the ischemic heart and, based on dual intra/extracellular function of some other interleukins, we hypothesized that IL-1Ra may also directly inhibit mitochondria-activated caspases and cardiomyocyte apoptosis.
- Publication
PloS one, 2013, Vol 8, Issue 1, pe53265
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0053265